Propofol infusion syndrome: Which Medications Cause It? (433 Reports Across 32 Drugs)
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Propofol infusion syndrome has been reported as an adverse event with 32 different drugs in the FDA's FAERS database, with 433 total reports. 171 of these reports resulted in death.The drugs most commonly associated with Propofol infusion syndrome are PROPOFOL, LEVETIRACETAM, and MIDAZOLAM.
433
Total Reports
32
Drugs Involved
171
Deaths
201
Hospitalizations
33.7 yrs
Average Patient Age
39.1% / 60.9%
Female / Male
Which Drugs Cause Propofol infusion syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| PROPOFOL | 420 | 2.6% | 169 | 193 | 148 |
| LEVETIRACETAM | 60 | 0.1% | 38 | 32 | 25 |
| MIDAZOLAM | 58 | 0.5% | 37 | 37 | 27 |
| DEXAMETHASONE | 51 | 0.0% | 38 | 34 | 35 |
| LACOSAMIDE | 50 | 0.2% | 34 | 31 | 23 |
| VALPROIC ACID | 45 | 0.2% | 36 | 32 | 24 |
| KETAMINE | 43 | 0.5% | 36 | 31 | 26 |
| TOPIRAMATE | 39 | 0.1% | 35 | 30 | 23 |
| CLOBAZAM | 36 | 0.3% | 33 | 27 | 22 |
| PENTOBARBITAL | 36 | 8.1% | 33 | 28 | 21 |
| ISOFLURANE | 35 | 4.2% | 34 | 26 | 22 |
| NOREPINEPHRINE | 34 | 0.7% | 7 | 22 | 13 |
| MAGNESIUM | 33 | 0.3% | 33 | 25 | 21 |
| OXCARBAZEPINE | 33 | 0.3% | 33 | 25 | 21 |
| LORAZEPAM | 30 | 0.1% | 22 | 27 | 25 |
| HUMAN IMMUNOGLOBULIN G | 28 | 0.0% | 25 | 24 | 18 |
| PHENYTOIN | 23 | 0.2% | 12 | 16 | 13 |
| METHYLPREDNISOLONE | 14 | 0.0% | 0 | 7 | 7 |
| PHENOBARBITAL | 12 | 0.2% | 3 | 9 | 3 |
| DIAZEPAM | 11 | 0.0% | 5 | 4 | 2 |