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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Toe amputation: Which Medications Cause It? (4,165 Reports Across 137 Drugs)

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Toe amputation has been reported as an adverse event with 137 different drugs in the FDA's FAERS database, with 4,165 total reports. 103 of these reports resulted in death.The drugs most commonly associated with Toe amputation are CANAGLIFLOZIN, CANAGLIFLOZIN\METFORMIN, and EMPAGLIFLOZIN.

4,165
Total Reports
137
Drugs Involved
103
Deaths
2,774
Hospitalizations
58.8 yrs
Average Patient Age
32.6% / 67.4%
Female / Male

Which Drugs Cause Toe amputation Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
CANAGLIFLOZIN 2,193 9.0% 19 1,647 6
CANAGLIFLOZIN\METFORMIN 196 12.7% 2 145 1
EMPAGLIFLOZIN 149 0.4% 0 78 9
INSULIN GLARGINE 133 0.1% 1 63 1
ADALIMUMAB 124 0.0% 1 36 2
METFORMIN 103 0.1% 1 76 2
BECAPLERMIN 102 5.0% 1 64 0
ETANERCEPT 100 0.0% 0 12 0
METHOTREXATE 84 0.0% 2 20 0
TOCILIZUMAB 66 0.1% 0 8 0
DAPAGLIFLOZIN 64 0.3% 2 41 2
INSULIN ASPART 55 0.3% 1 33 0
RITUXIMAB 55 0.0% 1 8 1
HYDROXYCHLOROQUINE 48 0.1% 0 0 0
INSULIN DETEMIR 39 0.4% 0 19 0
SULFASALAZINE 38 0.1% 0 1 0
MACITENTAN 36 0.1% 6 31 1
RISANKIZUMAB-RZAA 35 0.1% 0 13 0
DARBEPOETIN ALFA 30 0.1% 10 29 0
INSULIN HUMAN 29 0.1% 0 18 1

View all 137 drugs →

Top 3 Drugs Associated With Toe amputation

2,193 reports
149 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)