Does IRINOTECAN Cause Hyperammonaemia? 63 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 63 reports of Hyperammonaemia have been filed in association with IRINOTECAN (Irinotecan Hydrochloride). This represents 0.2% of all adverse event reports for IRINOTECAN.
63
Reports of Hyperammonaemia with IRINOTECAN
0.2%
of all IRINOTECAN reports
1
Deaths
39
Hospitalizations
How Dangerous Is Hyperammonaemia From IRINOTECAN?
Of the 63 reports, 1 (1.6%) resulted in death, 39 (61.9%) required hospitalization, and 14 (22.2%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for IRINOTECAN. However, 63 reports have been filed with the FAERS database.
What Other Side Effects Does IRINOTECAN Cause?
Diarrhoea (4,157)
Neutropenia (2,533)
Nausea (2,374)
Disease progression (2,018)
Off label use (2,018)
Vomiting (1,944)
Fatigue (1,515)
Febrile neutropenia (1,357)
Anaemia (1,231)
Thrombocytopenia (1,214)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
FLUOROURACIL (263)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
Which IRINOTECAN Alternatives Have Lower Hyperammonaemia Risk?
IRINOTECAN vs IRON
IRINOTECAN vs IRON DEXTRAN
IRINOTECAN vs IRON ISOMALTOSIDE 1000
IRINOTECAN vs IRON POLYMALTOSE
IRINOTECAN vs IRON SUCROSE