Does IRINOTECAN Cause Intestinal perforation? 144 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 144 reports of Intestinal perforation have been filed in association with IRINOTECAN (Irinotecan Hydrochloride). This represents 0.5% of all adverse event reports for IRINOTECAN.
144
Reports of Intestinal perforation with IRINOTECAN
0.5%
of all IRINOTECAN reports
51
Deaths
63
Hospitalizations
How Dangerous Is Intestinal perforation From IRINOTECAN?
Of the 144 reports, 51 (35.4%) resulted in death, 63 (43.8%) required hospitalization, and 17 (11.8%) were considered life-threatening.
Is Intestinal perforation Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for IRINOTECAN. However, 144 reports have been filed with the FAERS database.
What Other Side Effects Does IRINOTECAN Cause?
Diarrhoea (4,157)
Neutropenia (2,533)
Nausea (2,374)
Disease progression (2,018)
Off label use (2,018)
Vomiting (1,944)
Fatigue (1,515)
Febrile neutropenia (1,357)
Anaemia (1,231)
Thrombocytopenia (1,214)
What Other Drugs Cause Intestinal perforation?
ADALIMUMAB (1,010)
BEVACIZUMAB (600)
RITUXIMAB (321)
TOCILIZUMAB (276)
PREDNISONE (266)
CYCLOPHOSPHAMIDE (262)
DOXORUBICIN (240)
LENVATINIB (228)
INFLIXIMAB (226)
PEMBROLIZUMAB (220)
Which IRINOTECAN Alternatives Have Lower Intestinal perforation Risk?
IRINOTECAN vs IRON
IRINOTECAN vs IRON DEXTRAN
IRINOTECAN vs IRON ISOMALTOSIDE 1000
IRINOTECAN vs IRON POLYMALTOSE
IRINOTECAN vs IRON SUCROSE