Does IRINOTECAN Cause Neurotoxicity? 346 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 346 reports of Neurotoxicity have been filed in association with IRINOTECAN (Irinotecan Hydrochloride). This represents 1.2% of all adverse event reports for IRINOTECAN.
346
Reports of Neurotoxicity with IRINOTECAN
1.2%
of all IRINOTECAN reports
15
Deaths
48
Hospitalizations
How Dangerous Is Neurotoxicity From IRINOTECAN?
Of the 346 reports, 15 (4.3%) resulted in death, 48 (13.9%) required hospitalization, and 8 (2.3%) were considered life-threatening.
Is Neurotoxicity Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for IRINOTECAN. However, 346 reports have been filed with the FAERS database.
What Other Side Effects Does IRINOTECAN Cause?
Diarrhoea (4,157)
Neutropenia (2,533)
Nausea (2,374)
Disease progression (2,018)
Off label use (2,018)
Vomiting (1,944)
Fatigue (1,515)
Febrile neutropenia (1,357)
Anaemia (1,231)
Thrombocytopenia (1,214)
What Other Drugs Cause Neurotoxicity?
AXICABTAGENE CILOLEUCEL (1,327)
OXALIPLATIN (1,272)
METHOTREXATE (1,083)
CYCLOPHOSPHAMIDE (763)
FLUOROURACIL (735)
PACLITAXEL (734)
TACROLIMUS (623)
BEVACIZUMAB (588)
VINCRISTINE (555)
CAPECITABINE (553)
Which IRINOTECAN Alternatives Have Lower Neurotoxicity Risk?
IRINOTECAN vs IRON
IRINOTECAN vs IRON DEXTRAN
IRINOTECAN vs IRON ISOMALTOSIDE 1000
IRINOTECAN vs IRON POLYMALTOSE
IRINOTECAN vs IRON SUCROSE