Does ISONIAZID Cause Intestinal perforation? 15 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 15 reports of Intestinal perforation have been filed in association with ISONIAZID (Isoniazid). This represents 0.2% of all adverse event reports for ISONIAZID.
15
Reports of Intestinal perforation with ISONIAZID
0.2%
of all ISONIAZID reports
3
Deaths
9
Hospitalizations
How Dangerous Is Intestinal perforation From ISONIAZID?
Of the 15 reports, 3 (20.0%) resulted in death, 9 (60.0%) required hospitalization.
Is Intestinal perforation Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for ISONIAZID. However, 15 reports have been filed with the FAERS database.
What Other Side Effects Does ISONIAZID Cause?
Drug-induced liver injury (766)
Drug ineffective (607)
Drug reaction with eosinophilia and systemic symptoms (550)
Pyrexia (517)
Nausea (488)
Paradoxical drug reaction (433)
Off label use (406)
Drug resistance (367)
Hepatotoxicity (349)
Headache (324)
What Other Drugs Cause Intestinal perforation?
ADALIMUMAB (1,010)
BEVACIZUMAB (600)
RITUXIMAB (321)
TOCILIZUMAB (276)
PREDNISONE (266)
CYCLOPHOSPHAMIDE (262)
DOXORUBICIN (240)
LENVATINIB (228)
INFLIXIMAB (226)
PEMBROLIZUMAB (220)
Which ISONIAZID Alternatives Have Lower Intestinal perforation Risk?
ISONIAZID vs ISONIAZID\PYRAZINAMIDE\RIFAMPIN
ISONIAZID vs ISONIAZID\PYRIDOXINE\SULFAMETHOXAZOLE\TRIMETHOPRIM
ISONIAZID vs ISONIAZID\RIFAMPIN
ISONIAZID vs ISOPROPANOLAMINE
ISONIAZID vs ISOPROPYL ALCOHOL