Does METHOTREXATE Cause Acute hepatic failure? 285 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 285 reports of Acute hepatic failure have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
285
Reports of Acute hepatic failure with METHOTREXATE
0.1%
of all METHOTREXATE reports
174
Deaths
191
Hospitalizations
How Dangerous Is Acute hepatic failure From METHOTREXATE?
Of the 285 reports, 174 (61.1%) resulted in death, 191 (67.0%) required hospitalization, and 96 (33.7%) were considered life-threatening.
Is Acute hepatic failure Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 285 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Acute hepatic failure?
ACETAMINOPHEN (3,141)
PREDNISONE (439)
IBUPROFEN (412)
RITUXIMAB (412)
CYCLOPHOSPHAMIDE (411)
DOXORUBICIN (385)
VINCRISTINE (346)
PREDNISOLONE (301)
DEXAMETHASONE (249)
RIFAMPIN (210)
Which METHOTREXATE Alternatives Have Lower Acute hepatic failure Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA