Acute hepatic failure: Which Medications Cause It? (9,989 Reports Across 557 Drugs)
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Acute hepatic failure has been reported as an adverse event with 557 different drugs in the FDA's FAERS database, with 9,989 total reports. 3,697 of these reports resulted in death.The drugs most commonly associated with Acute hepatic failure are ACETAMINOPHEN, PREDNISONE, and IBUPROFEN.
9,989
Total Reports
557
Drugs Involved
3,697
Deaths
6,960
Hospitalizations
45.5 yrs
Average Patient Age
57.7% / 42.3%
Female / Male
Which Drugs Cause Acute hepatic failure Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ACETAMINOPHEN | 3,141 | 2.3% | 852 | 2,451 | 757 |
| PREDNISONE | 439 | 0.3% | 285 | 265 | 74 |
| IBUPROFEN | 412 | 0.5% | 51 | 341 | 99 |
| RITUXIMAB | 412 | 0.2% | 329 | 203 | 64 |
| CYCLOPHOSPHAMIDE | 411 | 0.3% | 299 | 187 | 51 |
| DOXORUBICIN | 385 | 0.5% | 262 | 172 | 31 |
| VINCRISTINE | 346 | 0.5% | 241 | 178 | 54 |
| PREDNISOLONE | 301 | 0.4% | 181 | 204 | 52 |
| METHOTREXATE | 285 | 0.1% | 174 | 191 | 96 |
| DEXAMETHASONE | 249 | 0.2% | 182 | 167 | 53 |
| RIFAMPIN | 210 | 1.6% | 41 | 141 | 35 |
| ISONIAZID | 206 | 2.7% | 45 | 139 | 29 |
| METHYLPREDNISOLONE | 192 | 0.3% | 146 | 133 | 84 |
| MYCOPHENOLATE MOFETIL | 184 | 0.3% | 116 | 122 | 64 |
| AMIODARONE | 181 | 0.7% | 43 | 113 | 60 |
| TACROLIMUS | 175 | 0.2% | 113 | 117 | 54 |
| PYRAZINAMIDE | 170 | 3.1% | 30 | 117 | 22 |
| ATORVASTATIN | 158 | 0.2% | 65 | 84 | 26 |
| LEVETIRACETAM | 156 | 0.3% | 66 | 106 | 24 |
| METFORMIN | 156 | 0.2% | 61 | 102 | 61 |