Does METHOTREXATE Cause Exostosis? 968 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 968 reports of Exostosis have been filed in association with METHOTREXATE (Methotrexate). This represents 0.4% of all adverse event reports for METHOTREXATE.
968
Reports of Exostosis with METHOTREXATE
0.4%
of all METHOTREXATE reports
451
Deaths
488
Hospitalizations
How Dangerous Is Exostosis From METHOTREXATE?
Of the 968 reports, 451 (46.6%) resulted in death, 488 (50.4%) required hospitalization, and 365 (37.7%) were considered life-threatening.
Is Exostosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 968 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Exostosis?
ADALIMUMAB (2,008)
ETANERCEPT (918)
ABATACEPT (775)
TOCILIZUMAB (768)
LEFLUNOMIDE (743)
SULFASALAZINE (712)
DICLOFENAC (702)
TOFACITINIB (702)
CERTOLIZUMAB PEGOL (695)
ALENDRONATE (686)
Which METHOTREXATE Alternatives Have Lower Exostosis Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA