Does METHOTREXATE Cause Hepatosplenomegaly? 149 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 149 reports of Hepatosplenomegaly have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
149
Reports of Hepatosplenomegaly with METHOTREXATE
0.1%
of all METHOTREXATE reports
27
Deaths
91
Hospitalizations
How Dangerous Is Hepatosplenomegaly From METHOTREXATE?
Of the 149 reports, 27 (18.1%) resulted in death, 91 (61.1%) required hospitalization, and 19 (12.8%) were considered life-threatening.
Is Hepatosplenomegaly Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 149 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Hepatosplenomegaly?
PREDNISONE (91)
CYCLOPHOSPHAMIDE (87)
RITUXIMAB (87)
VINCRISTINE (81)
DEXAMETHASONE (80)
PREDNISOLONE (72)
TACROLIMUS (71)
ETOPOSIDE (69)
RUXOLITINIB (61)
CYCLOSPORINE (59)
Which METHOTREXATE Alternatives Have Lower Hepatosplenomegaly Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA