Hepatosplenomegaly: Which Medications Cause It? (1,476 Reports Across 222 Drugs)
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Hepatosplenomegaly has been reported as an adverse event with 222 different drugs in the FDA's FAERS database, with 1,476 total reports. 317 of these reports resulted in death.The drugs most commonly associated with Hepatosplenomegaly are METHOTREXATE, PREDNISONE, and CYCLOPHOSPHAMIDE.
1,476
Total Reports
222
Drugs Involved
317
Deaths
904
Hospitalizations
38.1 yrs
Average Patient Age
41.2% / 58.8%
Female / Male
Which Drugs Cause Hepatosplenomegaly Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| METHOTREXATE | 149 | 0.1% | 27 | 91 | 19 |
| PREDNISONE | 91 | 0.1% | 25 | 55 | 12 |
| CYCLOPHOSPHAMIDE | 87 | 0.1% | 27 | 20 | 5 |
| RITUXIMAB | 87 | 0.1% | 22 | 31 | 18 |
| VINCRISTINE | 81 | 0.1% | 26 | 23 | 8 |
| DEXAMETHASONE | 80 | 0.1% | 33 | 47 | 21 |
| PREDNISOLONE | 72 | 0.1% | 23 | 21 | 11 |
| TACROLIMUS | 71 | 0.1% | 14 | 59 | 5 |
| ETOPOSIDE | 69 | 0.1% | 35 | 25 | 13 |
| RUXOLITINIB | 61 | 0.1% | 19 | 37 | 1 |
| CYCLOSPORINE | 59 | 0.1% | 14 | 32 | 11 |
| DOXORUBICIN | 56 | 0.1% | 19 | 10 | 4 |
| MYCOPHENOLATE MOFETIL | 56 | 0.1% | 7 | 29 | 3 |
| LAMOTRIGINE | 55 | 0.1% | 1 | 49 | 14 |
| SULFAMETHOXAZOLE\TRIMETHOPRIM | 54 | 0.1% | 3 | 53 | 1 |
| AZATHIOPRINE | 53 | 0.2% | 19 | 43 | 13 |
| CYTARABINE | 47 | 0.1% | 19 | 23 | 10 |
| AMPHOTERICIN B | 46 | 0.4% | 3 | 41 | 4 |
| PANTOPRAZOLE | 46 | 0.1% | 0 | 45 | 3 |
| FUROSEMIDE | 43 | 0.1% | 0 | 43 | 2 |