Does METHOTREXATE Cause Hyperammonaemic encephalopathy? 25 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 25 reports of Hyperammonaemic encephalopathy have been filed in association with METHOTREXATE (Methotrexate). This represents 0.0% of all adverse event reports for METHOTREXATE.
25
Reports of Hyperammonaemic encephalopathy with METHOTREXATE
0.0%
of all METHOTREXATE reports
15
Deaths
16
Hospitalizations
How Dangerous Is Hyperammonaemic encephalopathy From METHOTREXATE?
Of the 25 reports, 15 (60.0%) resulted in death, 16 (64.0%) required hospitalization, and 11 (44.0%) were considered life-threatening.
Is Hyperammonaemic encephalopathy Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 25 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Hyperammonaemic encephalopathy?
VALPROIC ACID (455)
FLUOROURACIL (156)
VALPROATE (120)
DIVALPROEX (119)
OXALIPLATIN (107)
TOPIRAMATE (101)
RISPERIDONE (96)
QUETIAPINE (91)
LEVETIRACETAM (71)
LEUCOVORIN (62)
Which METHOTREXATE Alternatives Have Lower Hyperammonaemic encephalopathy Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA