Hyperammonaemic encephalopathy: Which Medications Cause It? (1,381 Reports Across 124 Drugs)
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Hyperammonaemic encephalopathy has been reported as an adverse event with 124 different drugs in the FDA's FAERS database, with 1,381 total reports. 157 of these reports resulted in death.The drugs most commonly associated with Hyperammonaemic encephalopathy are VALPROIC ACID, FLUOROURACIL, and VALPROATE.
1,381
Total Reports
124
Drugs Involved
157
Deaths
923
Hospitalizations
43.1 yrs
Average Patient Age
44.9% / 55.1%
Female / Male
Which Drugs Cause Hyperammonaemic encephalopathy Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| VALPROIC ACID | 455 | 2.3% | 34 | 318 | 98 |
| FLUOROURACIL | 156 | 0.3% | 11 | 81 | 39 |
| VALPROATE | 120 | 0.8% | 4 | 80 | 18 |
| DIVALPROEX | 119 | 1.0% | 9 | 73 | 14 |
| OXALIPLATIN | 107 | 0.2% | 11 | 54 | 24 |
| TOPIRAMATE | 101 | 0.4% | 0 | 73 | 5 |
| RISPERIDONE | 96 | 0.1% | 0 | 62 | 16 |
| QUETIAPINE | 91 | 0.1% | 0 | 66 | 23 |
| LEVETIRACETAM | 71 | 0.1% | 5 | 45 | 18 |
| LEUCOVORIN | 62 | 0.3% | 8 | 28 | 14 |
| CAPECITABINE | 60 | 0.1% | 1 | 37 | 10 |
| OLANZAPINE | 54 | 0.1% | 0 | 41 | 18 |
| PREDNISONE | 45 | 0.0% | 7 | 39 | 19 |
| CISPLATIN | 44 | 0.1% | 1 | 29 | 4 |
| CARBAMAZEPINE | 42 | 0.2% | 1 | 34 | 2 |
| DEXAMETHASONE | 40 | 0.0% | 14 | 30 | 18 |
| PHENYTOIN | 40 | 0.3% | 3 | 28 | 3 |
| LORAZEPAM | 37 | 0.1% | 0 | 21 | 7 |
| ZONISAMIDE | 33 | 0.7% | 0 | 27 | 10 |
| TACROLIMUS | 32 | 0.0% | 8 | 19 | 10 |