Does METHOTREXATE Cause Liver injury? 3,601 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 3,601 reports of Liver injury have been filed in association with METHOTREXATE (Methotrexate). This represents 1.4% of all adverse event reports for METHOTREXATE.
3,601
Reports of Liver injury with METHOTREXATE
1.4%
of all METHOTREXATE reports
1,499
Deaths
1,731
Hospitalizations
How Dangerous Is Liver injury From METHOTREXATE?
Of the 3,601 reports, 1,499 (41.6%) resulted in death, 1,731 (48.1%) required hospitalization, and 1,783 (49.5%) were considered life-threatening.
Is Liver injury Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 3,601 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Liver injury?
ACETAMINOPHEN (3,002)
RITUXIMAB (2,692)
TOCILIZUMAB (2,637)
ADALIMUMAB (2,635)
PREDNISONE (2,611)
LEFLUNOMIDE (2,574)
ABATACEPT (2,572)
HYDROXYCHLOROQUINE (2,528)
DICLOFENAC (2,487)
SECUKINUMAB (2,441)
Which METHOTREXATE Alternatives Have Lower Liver injury Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA