Liver injury: Which Medications Cause It? (18,047 Reports Across 929 Drugs)
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Liver injury has been reported as an adverse event with 929 different drugs in the FDA's FAERS database, with 18,047 total reports. 3,111 of these reports resulted in death.The drugs most commonly associated with Liver injury are METHOTREXATE, ACETAMINOPHEN, and RITUXIMAB.
18,047
Total Reports
929
Drugs Involved
3,111
Deaths
7,818
Hospitalizations
51.2 yrs
Average Patient Age
63.2% / 36.8%
Female / Male
Which Drugs Cause Liver injury Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| METHOTREXATE | 3,601 | 1.4% | 1,499 | 1,731 | 1,783 |
| ACETAMINOPHEN | 3,002 | 2.2% | 1,473 | 1,992 | 1,635 |
| RITUXIMAB | 2,692 | 1.5% | 1,473 | 1,614 | 1,716 |
| TOCILIZUMAB | 2,637 | 2.7% | 1,436 | 1,488 | 1,623 |
| ADALIMUMAB | 2,635 | 0.5% | 1,382 | 1,490 | 1,665 |
| PREDNISONE | 2,611 | 1.7% | 1,417 | 1,552 | 1,690 |
| LEFLUNOMIDE | 2,574 | 4.6% | 1,415 | 1,536 | 1,775 |
| ABATACEPT | 2,572 | 2.2% | 1,285 | 1,426 | 1,713 |
| HYDROXYCHLOROQUINE | 2,528 | 3.8% | 1,357 | 1,459 | 1,619 |
| DICLOFENAC | 2,487 | 2.9% | 1,520 | 1,532 | 1,720 |
| SECUKINUMAB | 2,441 | 1.6% | 1,350 | 1,455 | 1,701 |
| CETIRIZINE | 2,401 | 5.0% | 1,374 | 1,402 | 1,647 |
| ALENDRONATE | 2,397 | 8.6% | 1,404 | 1,428 | 1,698 |
| SULFASALAZINE | 2,383 | 5.9% | 1,312 | 1,346 | 1,566 |
| FOLIC ACID | 2,380 | 10.4% | 1,381 | 1,404 | 1,648 |
| INFLIXIMAB | 2,357 | 1.7% | 1,287 | 1,326 | 1,539 |
| CERTOLIZUMAB PEGOL | 2,343 | 2.4% | 1,289 | 1,311 | 1,566 |
| DESOXIMETASONE | 2,327 | 20.0% | 1,357 | 1,338 | 1,636 |
| GOLIMUMAB | 2,309 | 3.3% | 1,278 | 1,307 | 1,534 |
| PHTHALYLSULFATHIAZOLE | 2,169 | 23.2% | 1,254 | 1,253 | 1,468 |