Does METHOTREXATE Cause Osteoarthritis? 4,979 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 4,979 reports of Osteoarthritis have been filed in association with METHOTREXATE (Methotrexate). This represents 2.0% of all adverse event reports for METHOTREXATE.
4,979
Reports of Osteoarthritis with METHOTREXATE
2.0%
of all METHOTREXATE reports
1,400
Deaths
2,524
Hospitalizations
How Dangerous Is Osteoarthritis From METHOTREXATE?
Of the 4,979 reports, 1,400 (28.1%) resulted in death, 2,524 (50.7%) required hospitalization, and 1,293 (26.0%) were considered life-threatening.
Is Osteoarthritis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 4,979 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Osteoarthritis?
ADALIMUMAB (8,893)
ETANERCEPT (4,124)
ABATACEPT (3,158)
RITUXIMAB (3,145)
LEFLUNOMIDE (3,131)
TOCILIZUMAB (2,986)
ALENDRONATE (2,851)
TOFACITINIB (2,831)
HYDROXYCHLOROQUINE (2,717)
SULFASALAZINE (2,601)
Which METHOTREXATE Alternatives Have Lower Osteoarthritis Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA