Does PEGASPARGASE Cause Necrosis? 20 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 20 reports of Necrosis have been filed in association with PEGASPARGASE (ONCASPAR). This represents 0.2% of all adverse event reports for PEGASPARGASE.
20
Reports of Necrosis with PEGASPARGASE
0.2%
of all PEGASPARGASE reports
5
Deaths
20
Hospitalizations
How Dangerous Is Necrosis From PEGASPARGASE?
Of the 20 reports, 5 (25.0%) resulted in death, 20 (100.0%) required hospitalization, and 1 (5.0%) were considered life-threatening.
Is Necrosis Listed in the Official Label?
Yes, Necrosis is listed as a known adverse reaction in the official FDA drug label for PEGASPARGASE.
What Other Side Effects Does PEGASPARGASE Cause?
Febrile neutropenia (1,589)
Pyrexia (706)
Febrile bone marrow aplasia (668)
Sepsis (548)
Vomiting (530)
Neutropenia (521)
Abdominal pain (469)
Hypertriglyceridaemia (399)
Hypotension (388)
Thrombocytopenia (382)
What Other Drugs Cause Necrosis?
METHOTREXATE (155)
PREDNISONE (143)
TACROLIMUS (120)
ADALIMUMAB (119)
MYCOPHENOLATE MOFETIL (101)
CYCLOPHOSPHAMIDE (97)
RITUXIMAB (97)
GLATIRAMER (84)
PREDNISOLONE (83)
METHYLPREDNISOLONE (76)
Which PEGASPARGASE Alternatives Have Lower Necrosis Risk?
PEGASPARGASE vs PEGASYS
PEGASPARGASE vs PEGCETACOPLAN
PEGASPARGASE vs PEGFILGRASTIM
PEGASPARGASE vs PEGFILGRASTIM-APGF
PEGASPARGASE vs PEGFILGRASTIM-BMEZ