Does PEMETREXED Cause Intestinal perforation? 37 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 37 reports of Intestinal perforation have been filed in association with PEMETREXED (Pemetrexed). This represents 0.2% of all adverse event reports for PEMETREXED.
37
Reports of Intestinal perforation with PEMETREXED
0.2%
of all PEMETREXED reports
17
Deaths
10
Hospitalizations
How Dangerous Is Intestinal perforation From PEMETREXED?
Of the 37 reports, 17 (45.9%) resulted in death, 10 (27.0%) required hospitalization, and 4 (10.8%) were considered life-threatening.
Is Intestinal perforation Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PEMETREXED. However, 37 reports have been filed with the FAERS database.
What Other Side Effects Does PEMETREXED Cause?
Malignant neoplasm progression (2,149)
Off label use (1,663)
Anaemia (1,430)
Pancytopenia (1,236)
Neutropenia (1,200)
Nausea (1,195)
Diarrhoea (1,165)
Acute kidney injury (1,105)
Thrombocytopenia (1,059)
Disease progression (969)
What Other Drugs Cause Intestinal perforation?
ADALIMUMAB (1,010)
BEVACIZUMAB (600)
RITUXIMAB (321)
TOCILIZUMAB (276)
PREDNISONE (266)
CYCLOPHOSPHAMIDE (262)
DOXORUBICIN (240)
LENVATINIB (228)
INFLIXIMAB (226)
PEMBROLIZUMAB (220)
Which PEMETREXED Alternatives Have Lower Intestinal perforation Risk?
PEMETREXED vs PEMIGATINIB
PEMETREXED vs PENICILLAMINE
PEMETREXED vs PENICILLIN
PEMETREXED vs PENICILLIN G
PEMETREXED vs PENICILLIN G BENZATHINE