Hyperkeratosis: Which Medications Cause It? (4,009 Reports Across 257 Drugs)
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Hyperkeratosis has been reported as an adverse event with 257 different drugs in the FDA's FAERS database, with 4,009 total reports. 148 of these reports resulted in death.The drugs most commonly associated with Hyperkeratosis are CABOZANTINIB S-MALATE, ADALIMUMAB, and SUNITINIB MALATE.
4,009
Total Reports
257
Drugs Involved
148
Deaths
994
Hospitalizations
61.4 yrs
Average Patient Age
53.8% / 46.2%
Female / Male
Which Drugs Cause Hyperkeratosis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CABOZANTINIB S-MALATE | 411 | 1.1% | 11 | 31 | 0 |
| ADALIMUMAB | 332 | 0.1% | 4 | 80 | 0 |
| SUNITINIB MALATE | 170 | 0.8% | 9 | 53 | 1 |
| ETANERCEPT | 168 | 0.1% | 0 | 28 | 0 |
| SORAFENIB | 150 | 1.4% | 12 | 48 | 3 |
| METHOTREXATE | 149 | 0.1% | 1 | 52 | 1 |
| VEMURAFENIB | 145 | 1.7% | 11 | 18 | 7 |
| REGORAFENIB | 136 | 1.4% | 5 | 35 | 1 |
| RIPRETINIB | 124 | 2.8% | 0 | 9 | 0 |
| RITUXIMAB | 121 | 0.1% | 9 | 29 | 8 |
| TOCILIZUMAB | 103 | 0.1% | 1 | 20 | 0 |
| DUPILUMAB | 96 | 0.0% | 0 | 12 | 0 |
| SECUKINUMAB | 95 | 0.1% | 3 | 18 | 0 |
| DABRAFENIB | 78 | 0.4% | 7 | 13 | 0 |
| NIVOLUMAB | 76 | 0.1% | 2 | 13 | 0 |
| LENVATINIB | 64 | 0.2% | 5 | 33 | 1 |
| AXITINIB | 55 | 0.4% | 3 | 11 | 0 |
| TOFACITINIB | 50 | 0.0% | 0 | 8 | 0 |
| INFLIXIMAB | 49 | 0.0% | 1 | 11 | 0 |
| CAPECITABINE | 48 | 0.1% | 7 | 12 | 0 |