Ototoxicity: Which Medications Cause It? (1,377 Reports Across 139 Drugs)
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Ototoxicity has been reported as an adverse event with 139 different drugs in the FDA's FAERS database, with 1,377 total reports. 42 of these reports resulted in death.The drugs most commonly associated with Ototoxicity are CISPLATIN, CARBOPLATIN, and VINCRISTINE.
1,377
Total Reports
139
Drugs Involved
42
Deaths
197
Hospitalizations
44.3 yrs
Average Patient Age
50.5% / 49.5%
Female / Male
Which Drugs Cause Ototoxicity Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CISPLATIN | 273 | 0.6% | 23 | 29 | 19 |
| CARBOPLATIN | 208 | 0.3% | 12 | 8 | 7 |
| VINCRISTINE | 194 | 0.3% | 2 | 7 | 10 |
| AMIKACIN | 158 | 1.4% | 6 | 34 | 2 |
| ETOPOSIDE | 121 | 0.2% | 6 | 10 | 2 |
| GENTAMICIN | 108 | 1.6% | 1 | 19 | 5 |
| CYCLOSPORINE | 105 | 0.2% | 0 | 3 | 1 |
| VANCOMYCIN | 87 | 0.3% | 0 | 35 | 7 |
| LINEZOLID | 82 | 0.5% | 3 | 20 | 2 |
| TOBRAMYCIN | 78 | 0.7% | 0 | 13 | 2 |
| CYCLOPHOSPHAMIDE | 76 | 0.1% | 4 | 14 | 10 |
| DOXORUBICIN | 73 | 0.1% | 1 | 9 | 1 |
| TENIPOSIDE | 71 | 22.4% | 0 | 0 | 0 |
| MOXIFLOXACIN | 63 | 0.4% | 3 | 18 | 1 |
| AZITHROMYCIN | 55 | 0.3% | 0 | 6 | 0 |
| PACLITAXEL | 55 | 0.1% | 4 | 4 | 2 |
| CLARITHROMYCIN | 54 | 0.3% | 3 | 27 | 3 |
| METHOTREXATE | 50 | 0.0% | 5 | 2 | 1 |
| CLOFAZIMINE | 49 | 1.1% | 1 | 12 | 2 |
| DEXAMETHASONE | 44 | 0.0% | 2 | 7 | 1 |