Spina bifida: Which Medications Cause It? (1,304 Reports Across 101 Drugs)
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Spina bifida has been reported as an adverse event with 101 different drugs in the FDA's FAERS database, with 1,304 total reports. 255 of these reports resulted in death.The drugs most commonly associated with Spina bifida are OXYCODONE, ACETAMINOPHEN\OXYCODONE, and ACETAMINOPHEN\HYDROCODONE.
1,304
Total Reports
101
Drugs Involved
255
Deaths
100
Hospitalizations
19.3 yrs
Average Patient Age
52.0% / 48.0%
Female / Male
Which Drugs Cause Spina bifida Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| OXYCODONE | 268 | 0.1% | 18 | 18 | 5 |
| ACETAMINOPHEN\OXYCODONE | 200 | 0.2% | 10 | 10 | 3 |
| ACETAMINOPHEN\HYDROCODONE | 188 | 0.2% | 11 | 16 | 4 |
| HYDROMORPHONE | 174 | 0.2% | 16 | 13 | 4 |
| MORPHINE | 159 | 0.1% | 12 | 12 | 3 |
| LAMOTRIGINE | 142 | 0.3% | 32 | 7 | 0 |
| TRAMADOL | 136 | 0.2% | 7 | 8 | 1 |
| BUPRENORPHINE | 107 | 0.1% | 4 | 4 | 1 |
| VALPROIC ACID | 101 | 0.5% | 24 | 5 | 0 |
| HYDROCODONE | 93 | 0.2% | 3 | 2 | 2 |
| LEVETIRACETAM | 91 | 0.2% | 15 | 2 | 12 |
| RITONAVIR | 87 | 0.7% | 33 | 10 | 11 |
| VALPROATE | 80 | 0.5% | 28 | 8 | 2 |
| DIVALPROEX | 71 | 0.6% | 10 | 2 | 2 |
| EMTRICITABINE | 66 | 1.8% | 45 | 0 | 0 |
| CLOBAZAM | 62 | 0.6% | 17 | 1 | 0 |
| PAROXETINE | 60 | 0.3% | 5 | 6 | 0 |
| EMTRICITABINE\TENOFOVIR DISOPROXIL | 56 | 0.1% | 32 | 10 | 11 |
| LOPINAVIR\RITONAVIR | 55 | 0.7% | 41 | 0 | 0 |
| ATAZANAVIR | 49 | 0.9% | 16 | 0 | 0 |