Stevens-johnson syndrome: Which Medications Cause It? (11,719 Reports Across 722 Drugs)
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Stevens-johnson syndrome has been reported as an adverse event with 722 different drugs in the FDA's FAERS database, with 11,719 total reports. 1,584 of these reports resulted in death.The drugs most commonly associated with Stevens-johnson syndrome are LAMOTRIGINE, ALLOPURINOL, and IBUPROFEN.
11,719
Total Reports
722
Drugs Involved
1,584
Deaths
6,841
Hospitalizations
49.6 yrs
Average Patient Age
56.8% / 43.2%
Female / Male
Which Drugs Cause Stevens-johnson syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| LAMOTRIGINE | 1,384 | 2.9% | 85 | 892 | 369 |
| ALLOPURINOL | 715 | 3.8% | 178 | 479 | 175 |
| IBUPROFEN | 711 | 0.8% | 19 | 532 | 155 |
| SULFAMETHOXAZOLE\TRIMETHOPRIM | 665 | 1.7% | 77 | 452 | 173 |
| ACETAMINOPHEN | 649 | 0.5% | 76 | 438 | 123 |
| CARBAMAZEPINE | 440 | 1.8% | 48 | 279 | 74 |
| PEMBROLIZUMAB | 395 | 0.5% | 118 | 288 | 89 |
| LEVETIRACETAM | 374 | 0.6% | 34 | 244 | 94 |
| CIPROFLOXACIN | 349 | 0.8% | 82 | 196 | 91 |
| VANCOMYCIN | 313 | 0.9% | 117 | 212 | 97 |
| PHENYTOIN | 306 | 2.1% | 40 | 203 | 72 |
| NIVOLUMAB | 295 | 0.3% | 53 | 190 | 67 |
| AMOXICILLIN | 284 | 0.9% | 36 | 215 | 67 |
| FUROSEMIDE | 231 | 0.5% | 67 | 132 | 51 |
| CEFTRIAXONE | 223 | 1.2% | 49 | 166 | 66 |
| PIPERACILLIN\TAZOBACTAM | 222 | 1.2% | 86 | 119 | 66 |
| FLUCONAZOLE | 207 | 1.4% | 40 | 140 | 88 |
| ASPIRIN | 205 | 0.2% | 44 | 100 | 39 |
| LEVOFLOXACIN | 200 | 0.5% | 35 | 128 | 28 |
| OMEPRAZOLE | 178 | 0.2% | 55 | 99 | 75 |