Amide Local Anesthetic [EPC] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Drug ineffective | 7,193 | 5 | 262 | 1,129 | 545 |
| Off label use | 3,599 | 4 | 273 | 781 | 302 |
| Product adhesion issue | 3,444 | 1 | 1 | 8 | 0 |
| Product quality issue | 3,264 | 3 | 9 | 41 | 10 |
| Drug ineffective for unapproved indication | 1,825 | 3 | 13 | 167 | 60 |
| Pain | 1,754 | 4 | 57 | 391 | 70 |
| Hypotension | 1,462 | 6 | 73 | 663 | 416 |
| Toxicity to various agents | 1,423 | 5 | 577 | 640 | 322 |
| Drug hypersensitivity | 1,369 | 5 | 80 | 168 | 107 |
| Dyspnoea | 1,288 | 4 | 119 | 484 | 220 |
| Vomiting | 1,121 | 4 | 169 | 373 | 138 |
| Nausea | 968 | 4 | 111 | 397 | 143 |
| Maternal exposure during pregnancy | 966 | 3 | 90 | 384 | 149 |
| Cardiac arrest | 935 | 4 | 313 | 449 | 493 |
| No adverse event | 883 | 3 | 3 | 20 | 2 |
| Product use in unapproved indication | 868 | 5 | 135 | 251 | 106 |
| Dizziness | 847 | 5 | 94 | 286 | 100 |
| Local anaesthetic systemic toxicity | 827 | 5 | 36 | 568 | 402 |
| Anaphylactic reaction | 789 | 5 | 26 | 278 | 260 |
| Hypoaesthesia | 785 | 5 | 90 | 266 | 82 |
| Exposure during pregnancy | 764 | 4 | 24 | 170 | 64 |
| Anaesthetic complication | 746 | 4 | 1 | 87 | 60 |
| Overdose | 702 | 6 | 151 | 378 | 188 |
| Anaphylactic shock | 699 | 4 | 63 | 216 | 411 |
| Bradycardia | 681 | 4 | 56 | 313 | 231 |
| Seizure | 653 | 4 | 92 | 299 | 191 |
| Pneumonia | 635 | 3 | 74 | 137 | 48 |
| Headache | 603 | 5 | 92 | 251 | 90 |
| Loss of consciousness | 596 | 4 | 60 | 283 | 146 |
| Hypertension | 583 | 4 | 131 | 350 | 190 |