Anthracycline Topoisomerase Inhibitor [EPC] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Febrile neutropenia | 11,722 | 4 | 1,449 | 7,092 | 1,642 |
| Off label use | 9,312 | 4 | 2,053 | 2,811 | 875 |
| Neutropenia | 7,831 | 4 | 1,208 | 2,845 | 1,216 |
| Disease progression | 6,894 | 4 | 1,639 | 972 | 201 |
| Drug ineffective | 5,627 | 4 | 1,677 | 1,445 | 601 |
| Pyrexia | 5,384 | 4 | 722 | 3,582 | 614 |
| Thrombocytopenia | 4,719 | 4 | 864 | 1,746 | 689 |
| Anaemia | 4,487 | 4 | 658 | 1,912 | 605 |
| Nausea | 4,472 | 4 | 400 | 2,025 | 328 |
| Product use in unapproved indication | 4,098 | 4 | 982 | 1,155 | 409 |
| Sepsis | 3,762 | 4 | 1,930 | 1,766 | 642 |
| Death | 3,671 | 4 | 3,669 | 394 | 126 |
| Vomiting | 3,568 | 4 | 436 | 1,812 | 318 |
| Diarrhoea | 3,473 | 4 | 557 | 1,793 | 307 |
| Pneumonia | 3,459 | 4 | 1,214 | 1,935 | 528 |
| Pancytopenia | 3,066 | 4 | 657 | 1,473 | 413 |
| Fatigue | 2,922 | 4 | 342 | 1,235 | 209 |
| Malignant neoplasm progression | 2,803 | 4 | 746 | 420 | 158 |
| Myelosuppression | 2,594 | 4 | 187 | 1,187 | 316 |
| Mucosal inflammation | 2,553 | 4 | 364 | 1,101 | 272 |
| Infection | 2,516 | 4 | 979 | 803 | 208 |
| Neuropathy peripheral | 2,447 | 4 | 234 | 476 | 96 |
| Dyspnoea | 2,368 | 4 | 365 | 1,385 | 252 |
| Leukopenia | 2,347 | 4 | 317 | 724 | 268 |
| Asthenia | 2,261 | 4 | 261 | 1,177 | 196 |
| Septic shock | 2,199 | 4 | 1,237 | 1,269 | 635 |
| White blood cell count decreased | 2,192 | 4 | 148 | 986 | 199 |
| Acute myeloid leukaemia | 2,097 | 4 | 998 | 583 | 389 |
| Cardiac failure | 1,955 | 4 | 531 | 972 | 284 |
| Acute kidney injury | 1,782 | 4 | 462 | 1,116 | 316 |