Antimetabolite [EPC] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Febrile neutropenia | 672 | 2 | 55 | 403 | 155 |
| Off label use | 613 | 2 | 81 | 210 | 36 |
| Drug ineffective | 399 | 3 | 87 | 117 | 27 |
| Anaemia | 384 | 2 | 53 | 211 | 34 |
| Pyrexia | 323 | 2 | 41 | 231 | 52 |
| Thrombocytopenia | 317 | 2 | 56 | 195 | 76 |
| Fatigue | 298 | 2 | 11 | 99 | 15 |
| Nausea | 268 | 2 | 8 | 114 | 17 |
| Diarrhoea | 246 | 3 | 25 | 122 | 32 |
| Pancytopenia | 221 | 2 | 43 | 144 | 53 |
| Platelet count decreased | 208 | 2 | 28 | 97 | 25 |
| Dyspnoea | 203 | 2 | 22 | 98 | 7 |
| Intentional product use issue | 201 | 1 | 11 | 49 | 8 |
| Product use in unapproved indication | 199 | 2 | 42 | 54 | 15 |
| Death | 191 | 2 | 189 | 37 | 8 |
| Pneumonia | 189 | 2 | 45 | 110 | 20 |
| Haemoglobin decreased | 188 | 2 | 23 | 86 | 16 |
| Headache | 187 | 2 | 7 | 81 | 7 |
| Vomiting | 184 | 2 | 12 | 118 | 20 |
| Neutropenia | 183 | 3 | 30 | 99 | 40 |
| Haematotoxicity | 183 | 2 | 30 | 7 | 0 |
| Platelet count increased | 174 | 1 | 3 | 44 | 9 |
| Skin ulcer | 173 | 1 | 7 | 60 | 3 |
| Asthenia | 173 | 2 | 8 | 104 | 12 |
| Pain | 169 | 2 | 12 | 88 | 16 |
| Splenomegaly | 142 | 1 | 13 | 56 | 7 |
| White blood cell count decreased | 136 | 2 | 29 | 59 | 12 |
| Sepsis | 136 | 2 | 44 | 85 | 20 |
| White blood cell count increased | 134 | 1 | 12 | 49 | 5 |
| Abdominal pain | 133 | 2 | 8 | 101 | 33 |