Proteasome Inhibitor [EPC] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Plasma cell myeloma | 12,170 | 3 | 2,675 | 1,638 | 322 |
| Off label use | 9,715 | 3 | 1,788 | 2,337 | 428 |
| Death | 6,312 | 3 | 6,301 | 822 | 179 |
| Neuropathy peripheral | 5,688 | 3 | 350 | 849 | 100 |
| Diarrhoea | 5,568 | 3 | 712 | 2,189 | 254 |
| Pneumonia | 4,619 | 3 | 1,129 | 3,085 | 484 |
| Thrombocytopenia | 4,311 | 3 | 885 | 1,504 | 436 |
| Fatigue | 4,261 | 3 | 450 | 1,098 | 147 |
| Drug ineffective | 3,960 | 3 | 747 | 826 | 300 |
| Nausea | 3,593 | 3 | 374 | 1,184 | 125 |
| Pyrexia | 2,996 | 3 | 442 | 1,887 | 264 |
| Anaemia | 2,984 | 3 | 658 | 1,238 | 221 |
| Neutropenia | 2,966 | 3 | 540 | 801 | 314 |
| Dyspnoea | 2,287 | 3 | 355 | 1,167 | 163 |
| Disease progression | 2,262 | 3 | 590 | 405 | 60 |
| Vomiting | 2,195 | 3 | 264 | 986 | 171 |
| Asthenia | 2,102 | 3 | 314 | 991 | 88 |
| Platelet count decreased | 2,074 | 3 | 362 | 810 | 138 |
| Rash | 2,005 | 3 | 132 | 556 | 54 |
| Acute kidney injury | 1,939 | 3 | 550 | 1,354 | 299 |
| Sepsis | 1,879 | 3 | 881 | 1,130 | 378 |
| Constipation | 1,869 | 3 | 221 | 644 | 72 |
| Infection | 1,771 | 3 | 595 | 740 | 137 |
| Intentional product use issue | 1,588 | 3 | 284 | 175 | 28 |
| Covid-19 | 1,553 | 3 | 433 | 797 | 97 |
| Plasma cell myeloma recurrent | 1,480 | 3 | 143 | 167 | 34 |
| Product use in unapproved indication | 1,457 | 3 | 328 | 382 | 131 |
| Malaise | 1,405 | 3 | 130 | 588 | 54 |
| Cardiac failure | 1,354 | 3 | 452 | 734 | 170 |
| Febrile neutropenia | 1,284 | 3 | 253 | 757 | 188 |