Does ASPARAGINASE Cause Hepatotoxicity? 86 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 86 reports of Hepatotoxicity have been filed in association with ASPARAGINASE (Rylaze). This represents 1.7% of all adverse event reports for ASPARAGINASE.
86
Reports of Hepatotoxicity with ASPARAGINASE
1.7%
of all ASPARAGINASE reports
3
Deaths
14
Hospitalizations
How Dangerous Is Hepatotoxicity From ASPARAGINASE?
Of the 86 reports, 3 (3.5%) resulted in death, 14 (16.3%) required hospitalization, and 13 (15.1%) were considered life-threatening.
Is Hepatotoxicity Listed in the Official Label?
Yes, Hepatotoxicity is listed as a known adverse reaction in the official FDA drug label for ASPARAGINASE.
What Other Side Effects Does ASPARAGINASE Cause?
Febrile neutropenia (557)
Neutropenia (322)
Bacterial infection (295)
Off label use (267)
Secondary immunodeficiency (233)
Viral infection (228)
Clostridium difficile colitis (213)
Pyrexia (204)
Sepsis (200)
Pneumonia (196)
What Other Drugs Cause Hepatotoxicity?
METHOTREXATE (1,917)
ACETAMINOPHEN (1,557)
LEFLUNOMIDE (829)
HYDROXYCHLOROQUINE (715)
PREDNISONE (707)
RITUXIMAB (702)
ETANERCEPT (699)
ADALIMUMAB (674)
CYCLOPHOSPHAMIDE (632)
SULFASALAZINE (613)
Which ASPARAGINASE Alternatives Have Lower Hepatotoxicity Risk?
ASPARAGINASE vs ASPARAGINASE ERWINIA CHRYSANTHEMI
ASPARAGINASE vs ASPARAGINASE ERWINIA CHRYSANTHEMI -RYWN
ASPARAGINASE vs ASPIRIN
ASPARAGINASE vs ASPIRIN DL-LYSINE
ASPARAGINASE vs ASPIRIN LYSINE