Leg amputation: Which Medications Cause It? (2,736 Reports Across 153 Drugs)
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Leg amputation has been reported as an adverse event with 153 different drugs in the FDA's FAERS database, with 2,736 total reports. 220 of these reports resulted in death.The drugs most commonly associated with Leg amputation are CANAGLIFLOZIN, INSULIN GLARGINE, and ADALIMUMAB.
2,736
Total Reports
153
Drugs Involved
220
Deaths
1,785
Hospitalizations
60.4 yrs
Average Patient Age
36.1% / 63.9%
Female / Male
Which Drugs Cause Leg amputation Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CANAGLIFLOZIN | 792 | 3.2% | 23 | 668 | 14 |
| INSULIN GLARGINE | 157 | 0.2% | 4 | 55 | 1 |
| ADALIMUMAB | 93 | 0.0% | 10 | 50 | 5 |
| METFORMIN | 79 | 0.1% | 12 | 51 | 6 |
| EMPAGLIFLOZIN | 67 | 0.2% | 2 | 39 | 4 |
| OXYCODONE | 67 | 0.0% | 11 | 22 | 2 |
| CANAGLIFLOZIN\METFORMIN | 62 | 4.0% | 1 | 58 | 1 |
| RIVAROXABAN | 58 | 0.0% | 6 | 30 | 2 |
| INSULIN ASPART | 49 | 0.2% | 2 | 23 | 0 |
| ETANERCEPT | 43 | 0.0% | 3 | 17 | 3 |
| DARBEPOETIN ALFA | 41 | 0.1% | 15 | 38 | 0 |
| ASPIRIN | 38 | 0.0% | 4 | 13 | 1 |
| HYDROMORPHONE | 37 | 0.0% | 5 | 22 | 1 |
| SITAGLIPTIN | 35 | 0.2% | 4 | 10 | 2 |
| INSULIN HUMAN | 34 | 0.1% | 1 | 15 | 0 |
| ACETAMINOPHEN\OXYCODONE | 33 | 0.0% | 8 | 12 | 1 |
| METHOTREXATE | 32 | 0.0% | 6 | 17 | 2 |
| ACETAMINOPHEN\HYDROCODONE | 31 | 0.0% | 5 | 11 | 1 |
| CINACALCET | 31 | 0.1% | 1 | 16 | 0 |
| MORPHINE | 29 | 0.0% | 7 | 9 | 1 |