Thrombotic microangiopathy: Which Medications Cause It? (7,465 Reports Across 340 Drugs)
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Thrombotic microangiopathy has been reported as an adverse event with 340 different drugs in the FDA's FAERS database, with 7,465 total reports. 1,296 of these reports resulted in death.The drugs most commonly associated with Thrombotic microangiopathy are TACROLIMUS, MYCOPHENOLATE MOFETIL, and CYCLOSPORINE.
7,465
Total Reports
340
Drugs Involved
1,296
Deaths
3,530
Hospitalizations
46.8 yrs
Average Patient Age
52.7% / 47.3%
Female / Male
Which Drugs Cause Thrombotic microangiopathy Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| TACROLIMUS | 1,982 | 2.2% | 307 | 859 | 184 |
| MYCOPHENOLATE MOFETIL | 820 | 1.1% | 165 | 300 | 68 |
| CYCLOSPORINE | 724 | 1.1% | 212 | 262 | 70 |
| GEMCITABINE | 648 | 2.1% | 102 | 351 | 121 |
| ECULIZUMAB | 636 | 1.4% | 133 | 264 | 29 |
| CYCLOPHOSPHAMIDE | 602 | 0.5% | 162 | 234 | 71 |
| FLUDARABINE | 480 | 2.0% | 157 | 96 | 22 |
| METHOTREXATE | 447 | 0.2% | 159 | 181 | 32 |
| CARFILZOMIB | 350 | 1.6% | 66 | 185 | 62 |
| METHYLPREDNISOLONE | 345 | 0.5% | 64 | 197 | 42 |
| MELPHALAN | 332 | 2.1% | 61 | 128 | 66 |
| PREDNISOLONE | 323 | 0.4% | 74 | 182 | 60 |
| PREDNISONE | 322 | 0.2% | 29 | 193 | 34 |
| BEVACIZUMAB | 310 | 0.4% | 12 | 127 | 22 |
| DEXAMETHASONE | 296 | 0.2% | 75 | 171 | 69 |
| BUSULFAN | 290 | 2.6% | 97 | 51 | 15 |
| RITUXIMAB | 278 | 0.2% | 80 | 138 | 27 |
| SIROLIMUS | 278 | 2.4% | 57 | 108 | 15 |
| ETOPOSIDE | 245 | 0.5% | 39 | 110 | 63 |
| GEMCITABINE\GEMCITABINE | 241 | 2.4% | 43 | 96 | 22 |