Does MESNA Cause Neurotoxicity? 54 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 54 reports of Neurotoxicity have been filed in association with MESNA (mesna). This represents 1.1% of all adverse event reports for MESNA.
54
Reports of Neurotoxicity with MESNA
1.1%
of all MESNA reports
4
Deaths
21
Hospitalizations
How Dangerous Is Neurotoxicity From MESNA?
Of the 54 reports, 4 (7.4%) resulted in death, 21 (38.9%) required hospitalization, and 1 (1.9%) were considered life-threatening.
Is Neurotoxicity Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for MESNA. However, 54 reports have been filed with the FAERS database.
What Other Side Effects Does MESNA Cause?
Febrile neutropenia (707)
Pyrexia (352)
Off label use (299)
Cystitis haemorrhagic (294)
Disease progression (273)
Neutropenia (238)
Encephalopathy (226)
Vomiting (200)
Death (184)
Pancytopenia (179)
What Other Drugs Cause Neurotoxicity?
AXICABTAGENE CILOLEUCEL (1,327)
OXALIPLATIN (1,272)
METHOTREXATE (1,083)
CYCLOPHOSPHAMIDE (763)
FLUOROURACIL (735)
PACLITAXEL (734)
TACROLIMUS (623)
BEVACIZUMAB (588)
VINCRISTINE (555)
CAPECITABINE (553)
Which MESNA Alternatives Have Lower Neurotoxicity Risk?
MESNA vs METAMIZOLE
MESNA vs METARAMINOL
MESNA vs METAXALONE
MESNA vs METFORMIN
MESNA vs METFORMIN\PIOGLITAZONE