Does PEGASPARGASE Cause Hepatotoxicity? 186 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 186 reports of Hepatotoxicity have been filed in association with PEGASPARGASE (ONCASPAR). This represents 1.6% of all adverse event reports for PEGASPARGASE.
186
Reports of Hepatotoxicity with PEGASPARGASE
1.6%
of all PEGASPARGASE reports
40
Deaths
78
Hospitalizations
How Dangerous Is Hepatotoxicity From PEGASPARGASE?
Of the 186 reports, 40 (21.5%) resulted in death, 78 (41.9%) required hospitalization, and 42 (22.6%) were considered life-threatening.
Is Hepatotoxicity Listed in the Official Label?
Yes, Hepatotoxicity is listed as a known adverse reaction in the official FDA drug label for PEGASPARGASE.
What Other Side Effects Does PEGASPARGASE Cause?
Febrile neutropenia (1,589)
Pyrexia (706)
Febrile bone marrow aplasia (668)
Sepsis (548)
Vomiting (530)
Neutropenia (521)
Abdominal pain (469)
Hypertriglyceridaemia (399)
Hypotension (388)
Thrombocytopenia (382)
What Other Drugs Cause Hepatotoxicity?
METHOTREXATE (1,917)
ACETAMINOPHEN (1,557)
LEFLUNOMIDE (829)
HYDROXYCHLOROQUINE (715)
PREDNISONE (707)
RITUXIMAB (702)
ETANERCEPT (699)
ADALIMUMAB (674)
CYCLOPHOSPHAMIDE (632)
SULFASALAZINE (613)
Which PEGASPARGASE Alternatives Have Lower Hepatotoxicity Risk?
PEGASPARGASE vs PEGASYS
PEGASPARGASE vs PEGCETACOPLAN
PEGASPARGASE vs PEGFILGRASTIM
PEGASPARGASE vs PEGFILGRASTIM-APGF
PEGASPARGASE vs PEGFILGRASTIM-BMEZ