Ammonium Ion Binding Activity [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Ammonia increased | 196 | 2 | 2 | 147 | 4 |
| Hyperammonaemia | 190 | 2 | 8 | 153 | 7 |
| Vomiting | 189 | 2 | 6 | 109 | 3 |
| Decreased appetite | 112 | 2 | 0 | 40 | 0 |
| Nausea | 90 | 2 | 1 | 25 | 0 |
| Off label use | 85 | 2 | 17 | 26 | 1 |
| Hyperammonaemic crisis | 79 | 2 | 6 | 68 | 2 |
| Headache | 74 | 2 | 1 | 20 | 1 |
| Diarrhoea | 67 | 2 | 2 | 26 | 1 |
| Fatigue | 57 | 2 | 1 | 11 | 0 |
| Seizure | 53 | 2 | 2 | 29 | 2 |
| Malaise | 49 | 2 | 1 | 20 | 2 |
| Somnolence | 47 | 1 | 1 | 24 | 1 |
| Death | 44 | 2 | 42 | 2 | 0 |
| Weight decreased | 43 | 1 | 1 | 13 | 0 |
| Dizziness | 40 | 2 | 1 | 7 | 0 |
| Abdominal pain upper | 40 | 2 | 0 | 9 | 0 |
| Lethargy | 39 | 1 | 2 | 20 | 0 |
| Amino acid level increased | 36 | 2 | 1 | 9 | 0 |
| Abdominal discomfort | 36 | 2 | 0 | 9 | 0 |
| Pyrexia | 35 | 2 | 3 | 22 | 0 |
| Influenza | 30 | 1 | 2 | 19 | 1 |
| Irritability | 29 | 2 | 1 | 11 | 2 |
| Liver transplant | 28 | 1 | 1 | 13 | 1 |
| Drug ineffective | 28 | 2 | 3 | 14 | 0 |
| Dehydration | 28 | 2 | 2 | 23 | 0 |
| Skin odour abnormal | 27 | 2 | 0 | 4 | 0 |
| Pneumonia | 27 | 2 | 8 | 22 | 2 |
| Drug dose omission | 27 | 1 | 1 | 13 | 0 |
| Nasopharyngitis | 26 | 1 | 0 | 12 | 0 |