Cytochrome P450 2C8 Inhibitors [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Death | 16,645 | 18 | 16,547 | 1,359 | 144 |
| Diarrhoea | 10,570 | 20 | 877 | 2,675 | 358 |
| Fatigue | 10,294 | 19 | 749 | 2,501 | 293 |
| Drug ineffective | 8,536 | 19 | 740 | 2,177 | 614 |
| Nausea | 8,008 | 19 | 722 | 2,660 | 273 |
| Seizure | 6,274 | 13 | 170 | 2,235 | 86 |
| Off label use | 6,133 | 19 | 692 | 2,434 | 338 |
| Gastrointestinal haemorrhage | 5,926 | 11 | 1,011 | 3,929 | 326 |
| Vomiting | 5,600 | 19 | 657 | 2,488 | 343 |
| Dyspnoea | 5,268 | 18 | 937 | 2,752 | 407 |
| Anaemia | 5,138 | 16 | 596 | 3,685 | 411 |
| Asthenia | 5,024 | 17 | 841 | 2,332 | 237 |
| Dizziness | 4,665 | 17 | 423 | 1,811 | 199 |
| Headache | 4,637 | 18 | 425 | 1,509 | 201 |
| Malaise | 4,473 | 17 | 645 | 1,738 | 244 |
| Decreased appetite | 4,207 | 17 | 666 | 1,445 | 174 |
| Pain | 4,059 | 16 | 383 | 1,583 | 176 |
| Hospitalisation | 4,054 | 15 | 229 | 3,924 | 30 |
| Rash | 4,004 | 18 | 149 | 832 | 121 |
| Drug interaction | 3,867 | 17 | 514 | 1,726 | 322 |
| Product use in unapproved indication | 3,721 | 14 | 425 | 829 | 127 |
| Weight decreased | 3,687 | 15 | 302 | 1,351 | 154 |
| Fall | 3,645 | 15 | 620 | 2,134 | 204 |
| Pyrexia | 3,357 | 18 | 631 | 1,951 | 262 |
| Hypertension | 3,287 | 16 | 283 | 1,156 | 198 |
| Pneumonia | 3,286 | 17 | 795 | 2,333 | 205 |
| Malignant neoplasm progression | 3,247 | 10 | 1,078 | 765 | 127 |
| Abdominal pain | 3,128 | 17 | 405 | 1,483 | 182 |
| Pruritus | 2,921 | 15 | 300 | 687 | 106 |
| Abdominal pain upper | 2,877 | 17 | 296 | 998 | 105 |