HER2/Neu/cerbB2 Antagonists [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Diarrhoea | 8,339 | 2 | 796 | 3,849 | 381 |
| Off label use | 5,688 | 2 | 1,174 | 1,800 | 180 |
| Nausea | 5,168 | 2 | 605 | 2,318 | 125 |
| Fatigue | 5,089 | 2 | 693 | 2,105 | 143 |
| Myelosuppression | 3,863 | 2 | 13 | 1,747 | 142 |
| Disease progression | 3,591 | 2 | 1,090 | 768 | 80 |
| Vomiting | 3,340 | 2 | 393 | 1,837 | 175 |
| Death | 3,185 | 2 | 3,183 | 314 | 57 |
| Dyspnoea | 2,997 | 2 | 319 | 1,611 | 198 |
| Pyrexia | 2,812 | 2 | 278 | 1,663 | 118 |
| Neuropathy peripheral | 2,716 | 2 | 389 | 842 | 56 |
| Asthenia | 2,551 | 2 | 380 | 998 | 91 |
| Neutropenia | 2,483 | 2 | 405 | 898 | 195 |
| Alopecia | 2,265 | 2 | 286 | 579 | 55 |
| Ejection fraction decreased | 2,223 | 2 | 221 | 642 | 107 |
| Rash | 2,203 | 2 | 73 | 598 | 85 |
| Anaemia | 2,184 | 2 | 220 | 883 | 201 |
| Headache | 2,048 | 2 | 172 | 900 | 60 |
| Decreased appetite | 1,847 | 2 | 256 | 911 | 49 |
| Metastases to central nervous system | 1,720 | 2 | 247 | 267 | 34 |
| Febrile neutropenia | 1,714 | 2 | 244 | 1,108 | 203 |
| Pain | 1,573 | 2 | 150 | 635 | 54 |
| Pneumonia | 1,516 | 2 | 377 | 998 | 112 |
| Drug ineffective | 1,516 | 2 | 174 | 230 | 61 |
| Cough | 1,496 | 2 | 253 | 732 | 95 |
| Chills | 1,482 | 2 | 66 | 484 | 93 |
| No adverse event | 1,473 | 2 | 3 | 2 | 0 |
| Thrombocytopenia | 1,467 | 2 | 228 | 523 | 132 |
| Constipation | 1,456 | 2 | 195 | 724 | 47 |
| Weight decreased | 1,422 | 2 | 188 | 648 | 36 |