Kallikrein Inhibitors [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Hereditary angioedema | 7,558 | 4 | 76 | 2,558 | 179 |
| Off label use | 1,836 | 4 | 814 | 1,058 | 789 |
| No adverse event | 1,699 | 3 | 59 | 270 | 65 |
| Drug ineffective | 1,680 | 4 | 525 | 882 | 512 |
| Weight increased | 1,306 | 4 | 431 | 788 | 406 |
| Product dose omission issue | 1,265 | 4 | 20 | 570 | 37 |
| Intentional product use issue | 1,125 | 2 | 535 | 571 | 457 |
| Product use in unapproved indication | 1,034 | 2 | 505 | 533 | 440 |
| Product use issue | 976 | 4 | 313 | 570 | 297 |
| Weight decreased | 956 | 4 | 73 | 496 | 85 |
| Pain | 955 | 4 | 504 | 624 | 484 |
| Headache | 918 | 4 | 386 | 539 | 411 |
| Nausea | 875 | 4 | 408 | 520 | 390 |
| Maternal exposure during pregnancy | 875 | 2 | 583 | 527 | 462 |
| Fatigue | 843 | 4 | 461 | 554 | 472 |
| Condition aggravated | 832 | 4 | 529 | 526 | 478 |
| Malaise | 830 | 4 | 334 | 511 | 338 |
| Swelling | 793 | 4 | 523 | 566 | 499 |
| Dizziness | 783 | 4 | 461 | 465 | 396 |
| Vomiting | 776 | 4 | 428 | 550 | 405 |
| Rash | 760 | 4 | 516 | 520 | 481 |
| Pneumonia | 711 | 3 | 423 | 547 | 351 |
| Dyspnoea | 702 | 4 | 309 | 535 | 323 |
| Arthralgia | 700 | 4 | 525 | 497 | 464 |
| Diarrhoea | 689 | 4 | 407 | 440 | 369 |
| Infusion related reaction | 680 | 2 | 578 | 523 | 504 |
| Urticaria | 679 | 4 | 452 | 444 | 383 |
| Nasopharyngitis | 675 | 4 | 427 | 423 | 367 |
| Peripheral swelling | 664 | 4 | 445 | 429 | 380 |
| Asthenia | 661 | 4 | 496 | 487 | 429 |