Programmed Death Receptor-1-directed Antibody Interactions [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Malignant neoplasm progression | 19,834 | 5 | 10,428 | 7,864 | 1,418 |
| Death | 19,612 | 6 | 19,600 | 2,139 | 337 |
| Off label use | 11,400 | 7 | 2,803 | 3,579 | 690 |
| Diarrhoea | 10,680 | 7 | 1,529 | 5,585 | 644 |
| Fatigue | 8,924 | 6 | 1,079 | 3,198 | 328 |
| Pyrexia | 8,462 | 7 | 1,244 | 5,946 | 638 |
| Rash | 6,811 | 6 | 693 | 2,539 | 364 |
| Nausea | 6,693 | 7 | 953 | 3,343 | 339 |
| Decreased appetite | 6,220 | 6 | 1,073 | 3,184 | 335 |
| Dyspnoea | 5,491 | 6 | 1,305 | 3,389 | 559 |
| Hypothyroidism | 5,319 | 6 | 638 | 2,112 | 332 |
| Pneumonia | 5,258 | 6 | 1,836 | 3,742 | 691 |
| Asthenia | 5,028 | 7 | 936 | 2,613 | 342 |
| Anaemia | 4,971 | 6 | 963 | 2,791 | 410 |
| Pneumonitis | 4,934 | 6 | 1,357 | 2,620 | 574 |
| Product use in unapproved indication | 4,599 | 6 | 1,191 | 1,218 | 187 |
| Interstitial lung disease | 4,503 | 6 | 1,611 | 2,612 | 571 |
| Colitis | 4,476 | 7 | 684 | 2,580 | 340 |
| Vomiting | 4,451 | 7 | 756 | 2,801 | 349 |
| Acute kidney injury | 4,419 | 6 | 775 | 3,386 | 650 |
| Intentional product use issue | 4,097 | 3 | 1,755 | 1,035 | 167 |
| Myelosuppression | 3,991 | 5 | 106 | 1,941 | 193 |
| Hypertension | 3,848 | 6 | 551 | 1,681 | 197 |
| Drug ineffective | 3,805 | 5 | 927 | 1,040 | 240 |
| Malaise | 3,706 | 5 | 672 | 2,034 | 195 |
| Pruritus | 3,660 | 6 | 267 | 1,184 | 112 |
| Neutropenia | 3,511 | 6 | 453 | 1,257 | 279 |
| Thrombocytopenia | 3,381 | 6 | 543 | 1,453 | 333 |
| Weight decreased | 3,345 | 6 | 367 | 1,407 | 162 |
| Arthralgia | 3,334 | 5 | 267 | 1,089 | 98 |