Does PEGASPARGASE Cause Hyperammonaemia? 44 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 44 reports of Hyperammonaemia have been filed in association with PEGASPARGASE (ONCASPAR). This represents 0.4% of all adverse event reports for PEGASPARGASE.
44
Reports of Hyperammonaemia with PEGASPARGASE
0.4%
of all PEGASPARGASE reports
19
Deaths
28
Hospitalizations
How Dangerous Is Hyperammonaemia From PEGASPARGASE?
Of the 44 reports, 19 (43.2%) resulted in death, 28 (63.6%) required hospitalization, and 9 (20.5%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PEGASPARGASE. However, 44 reports have been filed with the FAERS database.
What Other Side Effects Does PEGASPARGASE Cause?
Febrile neutropenia (1,589)
Pyrexia (706)
Febrile bone marrow aplasia (668)
Sepsis (548)
Vomiting (530)
Neutropenia (521)
Abdominal pain (469)
Hypertriglyceridaemia (399)
Hypotension (388)
Thrombocytopenia (382)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
FLUOROURACIL (263)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
Which PEGASPARGASE Alternatives Have Lower Hyperammonaemia Risk?
PEGASPARGASE vs PEGASYS
PEGASPARGASE vs PEGCETACOPLAN
PEGASPARGASE vs PEGFILGRASTIM
PEGASPARGASE vs PEGFILGRASTIM-APGF
PEGASPARGASE vs PEGFILGRASTIM-BMEZ