Antimetabolite Immunosuppressant [EPC] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Off label use | 15,448 | 3 | 2,599 | 5,034 | 1,677 |
| Drug ineffective | 9,405 | 3 | 1,659 | 3,204 | 1,371 |
| Product use in unapproved indication | 6,884 | 3 | 1,310 | 1,699 | 769 |
| Diarrhoea | 5,061 | 3 | 1,288 | 2,534 | 913 |
| Cytomegalovirus infection | 4,135 | 3 | 905 | 1,498 | 399 |
| Pyrexia | 3,909 | 3 | 1,502 | 2,622 | 1,015 |
| Pneumonia | 3,725 | 3 | 1,507 | 2,143 | 905 |
| Covid-19 | 3,655 | 3 | 739 | 2,505 | 432 |
| Condition aggravated | 3,414 | 3 | 933 | 1,636 | 1,004 |
| Transplant rejection | 3,165 | 3 | 313 | 975 | 277 |
| Acute kidney injury | 3,004 | 3 | 555 | 2,046 | 546 |
| Nausea | 2,946 | 3 | 848 | 1,460 | 635 |
| Fatigue | 2,906 | 3 | 1,168 | 1,556 | 900 |
| Infection | 2,789 | 3 | 1,485 | 1,465 | 806 |
| Vomiting | 2,724 | 3 | 1,241 | 1,684 | 901 |
| Sepsis | 2,586 | 3 | 1,536 | 1,194 | 446 |
| Death | 2,579 | 3 | 2,558 | 238 | 127 |
| Headache | 2,506 | 3 | 969 | 1,234 | 750 |
| Dyspnoea | 2,483 | 3 | 1,065 | 1,496 | 712 |
| Treatment failure | 2,478 | 3 | 505 | 712 | 448 |
| Hypertension | 2,349 | 3 | 938 | 1,282 | 845 |
| Post transplant lymphoproliferative disorder | 2,258 | 3 | 651 | 773 | 371 |
| Rash | 2,220 | 3 | 934 | 1,109 | 798 |
| Drug intolerance | 2,149 | 3 | 576 | 882 | 603 |
| Arthralgia | 2,124 | 3 | 918 | 1,107 | 727 |
| Leukopenia | 2,054 | 3 | 337 | 959 | 243 |
| Neutropenia | 2,028 | 3 | 329 | 895 | 188 |
| Malaise | 1,989 | 3 | 990 | 1,180 | 746 |
| Intentional product use issue | 1,926 | 3 | 682 | 853 | 515 |
| Multiple organ dysfunction syndrome | 1,915 | 3 | 1,667 | 1,112 | 611 |