Bisphosphonate [EPC] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Pain | 13,830 | 5 | 1,820 | 4,276 | 2,191 |
| Fatigue | 11,027 | 5 | 2,320 | 3,791 | 2,348 |
| Arthralgia | 10,517 | 5 | 2,131 | 4,194 | 2,070 |
| Drug ineffective | 10,239 | 5 | 1,385 | 3,553 | 1,849 |
| Abdominal discomfort | 9,219 | 5 | 1,734 | 2,958 | 2,131 |
| Alopecia | 9,107 | 5 | 1,694 | 2,783 | 2,150 |
| Rheumatoid arthritis | 8,706 | 5 | 1,866 | 3,372 | 2,242 |
| Systemic lupus erythematosus | 8,282 | 4 | 1,938 | 2,621 | 2,234 |
| Pemphigus | 8,049 | 2 | 1,723 | 2,374 | 2,134 |
| Osteonecrosis of jaw | 7,559 | 5 | 321 | 1,914 | 95 |
| Glossodynia | 7,420 | 4 | 1,908 | 2,409 | 2,135 |
| Rash | 7,327 | 5 | 1,830 | 3,106 | 2,181 |
| Swelling | 7,113 | 5 | 1,815 | 2,628 | 2,122 |
| Arthropathy | 6,731 | 5 | 1,662 | 2,850 | 2,054 |
| Nausea | 6,654 | 5 | 1,643 | 3,031 | 1,666 |
| Off label use | 6,477 | 5 | 1,909 | 3,268 | 2,326 |
| Hand deformity | 6,429 | 3 | 1,863 | 2,420 | 2,121 |
| Femur fracture | 6,341 | 5 | 194 | 4,361 | 67 |
| Dyspnoea | 6,290 | 5 | 1,846 | 2,956 | 1,657 |
| Contraindicated product administered | 6,227 | 4 | 1,171 | 2,189 | 1,517 |
| Pyrexia | 6,148 | 5 | 1,536 | 3,138 | 1,493 |
| Joint swelling | 6,134 | 5 | 1,811 | 2,705 | 2,141 |
| Headache | 6,104 | 5 | 1,849 | 2,712 | 1,758 |
| Infusion related reaction | 6,019 | 4 | 1,861 | 2,796 | 2,060 |
| Wound | 6,002 | 4 | 1,818 | 2,302 | 2,073 |
| Drug intolerance | 5,959 | 5 | 1,383 | 2,444 | 1,708 |
| Hypersensitivity | 5,858 | 5 | 1,587 | 2,664 | 1,976 |
| Diarrhoea | 5,782 | 5 | 2,003 | 2,723 | 1,762 |
| Pain in extremity | 5,774 | 5 | 1,138 | 2,617 | 1,302 |
| Synovitis | 5,636 | 4 | 1,795 | 2,715 | 2,102 |