Estradiol Congeners [CS] — Common Side Effects

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Side Effect	Total Reports	Drugs	Deaths	Hosp.	Life-Threat.
Product adhesion issue	4,774	1	0	20	5
Drug ineffective	4,047	2	12	61	17
Off label use	3,282	2	44	273	75
Hot flush	2,293	2	0	21	15
Wrong technique in product usage process	1,871	1	1	19	9
Product quality issue	1,677	2	0	20	10
Headache	1,519	2	5	132	28
No adverse event	1,493	1	0	0	0
Application site pruritus	1,181	1	0	0	0
Application site erythema	1,117	1	0	4	0
Application site rash	894	1	0	2	0
Nausea	846	2	9	112	23
Insomnia	826	2	9	49	19
Feeling abnormal	786	2	0	43	13
Rash	778	1	5	63	6
Vaginal haemorrhage	777	1	0	48	20
Product use issue	775	2	12	81	15
Vulvovaginal discomfort	757	1	0	15	0
Pruritus	730	2	4	23	6
Vulvovaginal burning sensation	704	1	0	8	0
Product substitution issue	692	1	0	5	10
Device adhesion issue	678	1	0	1	1
Vaginal discharge	661	1	0	14	1
Fatigue	648	2	8	69	13
Application site irritation	624	1	0	2	0
Product dose omission issue	616	2	0	12	2
Pain	603	2	7	80	12
Malaise	602	2	7	51	22
Anxiety	580	2	4	55	14
Incorrect dose administered	574	1	1	10	1