Estrogen Receptor Agonists [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Drug ineffective | 4,912 | 3 | 12 | 125 | 18 |
| Product adhesion issue | 4,774 | 1 | 0 | 20 | 5 |
| Off label use | 4,648 | 3 | 55 | 423 | 82 |
| Hot flush | 2,754 | 3 | 7 | 54 | 23 |
| Wrong technique in product usage process | 1,999 | 2 | 1 | 44 | 9 |
| Headache | 1,892 | 3 | 5 | 181 | 29 |
| Product quality issue | 1,824 | 3 | 0 | 32 | 10 |
| No adverse event | 1,522 | 2 | 0 | 0 | 0 |
| Product use issue | 1,210 | 3 | 14 | 141 | 15 |
| Feeling abnormal | 1,196 | 3 | 0 | 104 | 15 |
| Application site pruritus | 1,181 | 1 | 0 | 0 | 0 |
| Application site erythema | 1,122 | 2 | 0 | 5 | 0 |
| Malaise | 1,116 | 3 | 7 | 138 | 25 |
| Insomnia | 1,111 | 3 | 10 | 84 | 20 |
| Nausea | 1,027 | 3 | 15 | 143 | 30 |
| Vulvovaginal burning sensation | 981 | 2 | 0 | 28 | 0 |
| Pain | 972 | 3 | 8 | 155 | 16 |
| Vaginal haemorrhage | 951 | 2 | 1 | 71 | 20 |
| Fatigue | 935 | 3 | 15 | 152 | 21 |
| Vulvovaginal discomfort | 922 | 2 | 0 | 22 | 1 |
| Pruritus | 908 | 3 | 4 | 45 | 6 |
| Application site rash | 894 | 1 | 0 | 2 | 0 |
| Rash | 885 | 2 | 5 | 75 | 6 |
| Product use in unapproved indication | 777 | 2 | 11 | 160 | 31 |
| Weight increased | 752 | 3 | 6 | 75 | 13 |
| Anxiety | 751 | 3 | 4 | 78 | 14 |
| Vaginal discharge | 726 | 2 | 0 | 21 | 1 |
| Alopecia | 726 | 3 | 4 | 57 | 10 |
| Product substitution issue | 699 | 2 | 0 | 5 | 10 |
| Drug hypersensitivity | 691 | 2 | 29 | 65 | 30 |