Phosphodiesterase 4 Inhibitor [EPC] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Diarrhoea | 24,043 | 3 | 1,255 | 1,778 | 1,182 |
| Nausea | 21,552 | 3 | 1,069 | 1,725 | 1,056 |
| Psoriasis | 19,298 | 3 | 348 | 884 | 275 |
| Headache | 17,216 | 4 | 1,242 | 1,671 | 1,225 |
| Drug ineffective | 16,112 | 4 | 1,007 | 1,552 | 1,076 |
| Abdominal discomfort | 7,718 | 3 | 1,337 | 1,480 | 1,311 |
| Psoriatic arthropathy | 7,044 | 2 | 1,594 | 1,778 | 1,476 |
| Rash | 6,266 | 4 | 1,593 | 1,769 | 1,516 |
| Pain | 6,180 | 3 | 1,369 | 1,579 | 1,326 |
| Vomiting | 6,003 | 3 | 1,379 | 1,575 | 1,283 |
| Fatigue | 5,462 | 4 | 1,470 | 1,745 | 1,448 |
| Arthralgia | 5,400 | 2 | 1,347 | 1,531 | 1,290 |
| Off label use | 5,312 | 3 | 1,426 | 1,771 | 1,509 |
| Depression | 5,186 | 4 | 888 | 921 | 836 |
| Weight decreased | 4,921 | 3 | 550 | 804 | 534 |
| Product dose omission | 4,602 | 3 | 2 | 140 | 1 |
| Product dose omission issue | 4,515 | 4 | 4 | 92 | 3 |
| Abdominal pain upper | 4,452 | 2 | 1,041 | 1,172 | 1,074 |
| Malaise | 4,211 | 3 | 1,239 | 1,515 | 1,279 |
| Condition aggravated | 3,936 | 4 | 1,207 | 1,343 | 1,157 |
| Pruritus | 3,930 | 3 | 930 | 966 | 841 |
| Decreased appetite | 3,593 | 2 | 1,092 | 1,196 | 1,091 |
| Therapy non-responder | 3,360 | 1 | 339 | 517 | 389 |
| Insomnia | 3,210 | 4 | 839 | 1,061 | 806 |
| Adverse drug reaction | 3,168 | 2 | 411 | 452 | 459 |
| Dizziness | 3,117 | 4 | 981 | 967 | 888 |
| Nasopharyngitis | 2,827 | 3 | 1,145 | 1,057 | 995 |
| Alopecia | 2,788 | 2 | 1,351 | 1,379 | 1,333 |
| Rheumatoid arthritis | 2,754 | 2 | 1,576 | 1,668 | 1,492 |
| Joint swelling | 2,686 | 2 | 1,516 | 1,558 | 1,437 |