Cytochrome P450 2B6 Inducers [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Fatigue | 11,690 | 14 | 546 | 1,776 | 189 |
| Seizure | 11,259 | 14 | 336 | 3,443 | 327 |
| Death | 10,274 | 14 | 10,243 | 824 | 130 |
| Drug ineffective | 9,398 | 15 | 646 | 2,779 | 744 |
| Pyrexia | 7,109 | 15 | 838 | 3,471 | 434 |
| Hot flush | 7,029 | 9 | 28 | 358 | 9 |
| Off label use | 6,116 | 15 | 723 | 2,492 | 441 |
| Diarrhoea | 6,017 | 15 | 488 | 1,446 | 158 |
| Nausea | 5,597 | 15 | 413 | 1,785 | 159 |
| Dizziness | 5,231 | 15 | 309 | 1,260 | 152 |
| Foetal exposure during pregnancy | 5,150 | 8 | 823 | 564 | 95 |
| Rash | 5,069 | 15 | 242 | 1,443 | 277 |
| Asthenia | 4,693 | 14 | 504 | 1,378 | 143 |
| Headache | 4,428 | 14 | 326 | 1,206 | 148 |
| Vomiting | 4,369 | 15 | 436 | 2,028 | 223 |
| Product dose omission issue | 4,037 | 12 | 85 | 780 | 53 |
| Pain | 4,020 | 14 | 239 | 1,399 | 184 |
| Drug interaction | 4,018 | 15 | 419 | 1,549 | 274 |
| Somnolence | 3,965 | 15 | 286 | 1,041 | 112 |
| Toxicity to various agents | 3,925 | 12 | 888 | 2,371 | 469 |
| Product use in unapproved indication | 3,744 | 13 | 295 | 881 | 145 |
| Fall | 3,700 | 14 | 371 | 2,046 | 161 |
| Arthralgia | 3,606 | 13 | 287 | 611 | 74 |
| Therapy interrupted | 3,564 | 8 | 26 | 265 | 3 |
| Drug resistance | 3,273 | 11 | 257 | 305 | 35 |
| Malaise | 3,219 | 14 | 401 | 1,076 | 151 |
| Dyspnoea | 3,103 | 14 | 567 | 1,338 | 266 |
| Constipation | 2,927 | 12 | 111 | 1,175 | 114 |
| Incorrect dose administered | 2,915 | 9 | 169 | 428 | 31 |
| Weight increased | 2,793 | 12 | 52 | 390 | 35 |