Cytochrome P450 2C19 Inducers [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Fatigue | 12,115 | 9 | 783 | 1,967 | 153 |
| Death | 10,522 | 8 | 10,504 | 1,049 | 97 |
| Drug ineffective | 10,208 | 10 | 733 | 2,570 | 686 |
| Malignant neoplasm progression | 6,400 | 5 | 2,190 | 1,207 | 104 |
| Nausea | 6,070 | 10 | 477 | 1,805 | 135 |
| Pyrexia | 5,825 | 10 | 522 | 2,921 | 363 |
| Asthenia | 5,212 | 8 | 546 | 1,523 | 93 |
| Dizziness | 5,155 | 9 | 258 | 1,237 | 94 |
| Seizure | 4,992 | 7 | 258 | 1,579 | 287 |
| Diarrhoea | 4,550 | 10 | 378 | 1,263 | 122 |
| Off label use | 4,139 | 10 | 498 | 1,491 | 388 |
| Decreased appetite | 4,089 | 7 | 550 | 1,238 | 64 |
| Prostatic specific antigen increased | 3,731 | 1 | 321 | 463 | 22 |
| Fall | 3,713 | 7 | 336 | 2,170 | 149 |
| Toxicity to various agents | 3,610 | 7 | 837 | 2,241 | 449 |
| Vomiting | 3,588 | 10 | 328 | 1,765 | 172 |
| Headache | 3,540 | 9 | 162 | 897 | 93 |
| Rash | 3,524 | 10 | 214 | 1,150 | 227 |
| Hot flush | 3,257 | 6 | 124 | 291 | 12 |
| Pain | 3,234 | 8 | 236 | 1,308 | 144 |
| Drug interaction | 3,082 | 10 | 212 | 1,377 | 259 |
| Foetal exposure during pregnancy | 3,060 | 3 | 417 | 318 | 63 |
| Malaise | 2,967 | 8 | 368 | 1,107 | 95 |
| Arthralgia | 2,877 | 8 | 162 | 543 | 40 |
| Constipation | 2,873 | 8 | 204 | 1,166 | 97 |
| Dyspnoea | 2,523 | 9 | 318 | 1,076 | 217 |
| Back pain | 2,516 | 8 | 224 | 537 | 50 |
| Somnolence | 2,438 | 9 | 164 | 799 | 93 |
| Weight decreased | 2,412 | 7 | 207 | 650 | 43 |
| Hypotension | 2,369 | 7 | 193 | 1,487 | 318 |