Cytochrome P450 2C9 Inducers [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Fatigue | 14,180 | 12 | 1,296 | 3,236 | 602 |
| Death | 13,090 | 12 | 13,067 | 1,765 | 111 |
| Drug ineffective | 11,217 | 13 | 1,044 | 3,157 | 989 |
| Nausea | 7,620 | 13 | 824 | 2,777 | 406 |
| Pyrexia | 7,443 | 13 | 990 | 4,240 | 785 |
| Malignant neoplasm progression | 6,474 | 8 | 2,219 | 1,235 | 108 |
| Dizziness | 6,287 | 12 | 632 | 1,948 | 410 |
| Asthenia | 6,198 | 11 | 914 | 2,282 | 399 |
| Off label use | 6,102 | 13 | 959 | 2,427 | 801 |
| Dyspnoea | 6,092 | 12 | 1,114 | 3,473 | 651 |
| Diarrhoea | 5,918 | 13 | 844 | 2,277 | 454 |
| Seizure | 5,200 | 11 | 285 | 1,721 | 298 |
| Headache | 4,939 | 12 | 547 | 1,756 | 444 |
| Vomiting | 4,842 | 13 | 771 | 2,678 | 548 |
| Decreased appetite | 4,834 | 10 | 875 | 1,821 | 386 |
| Rash | 4,520 | 13 | 588 | 1,942 | 635 |
| Fall | 4,409 | 10 | 450 | 2,687 | 160 |
| Pain | 4,376 | 11 | 549 | 2,149 | 467 |
| Malaise | 4,354 | 11 | 796 | 1,926 | 430 |
| Arthralgia | 3,795 | 11 | 455 | 1,238 | 360 |
| Prostatic specific antigen increased | 3,731 | 1 | 321 | 463 | 22 |
| Toxicity to various agents | 3,646 | 9 | 841 | 2,271 | 457 |
| Hot flush | 3,316 | 7 | 128 | 314 | 17 |
| Drug interaction | 3,303 | 13 | 232 | 1,478 | 283 |
| Constipation | 3,254 | 11 | 232 | 1,337 | 107 |
| Pneumonia | 3,199 | 13 | 952 | 2,545 | 402 |
| Condition aggravated | 3,180 | 12 | 737 | 1,876 | 565 |
| Foetal exposure during pregnancy | 3,093 | 5 | 420 | 322 | 64 |
| Hypotension | 3,037 | 11 | 342 | 1,918 | 383 |
| Back pain | 3,007 | 11 | 300 | 773 | 117 |