Proton Pump Inhibitors [MoA] — Common Side Effects

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Side Effect	Total Reports	Drugs	Deaths	Hosp.	Life-Threat.
Chronic kidney disease	152,430	6	16,656	12,571	284
Acute kidney injury	80,402	6	11,449	13,122	832
Renal failure	63,159	6	11,784	9,972	328
End stage renal disease	44,939	6	9,931	5,638	274
Renal injury	40,038	6	3,470	4,483	65
Tubulointerstitial nephritis	19,585	6	2,797	3,227	280
Drug ineffective	17,334	6	1,211	4,557	1,238
Gastrooesophageal reflux disease	16,042	6	756	3,030	339
Off label use	13,194	6	1,900	4,934	1,838
Pain	12,949	6	1,132	3,850	1,570
Death	12,531	6	12,503	1,211	355
Nephrogenic anaemia	11,088	6	2,008	3,185	37
Diarrhoea	10,804	6	1,487	4,719	1,544
Nausea	10,670	6	1,539	4,453	1,699
Dyspnoea	10,587	6	1,628	5,637	1,950
Rebound acid hypersecretion	9,369	6	1,329	1,083	36
Fatigue	9,352	6	1,410	3,889	1,829
Headache	8,983	6	1,278	3,550	1,407
Renal impairment	8,431	6	1,071	1,597	213
Vomiting	8,285	6	1,770	4,268	1,883
Hyperchlorhydria	8,201	6	380	95	4
Malaise	7,966	6	1,135	3,657	1,472
Dizziness	7,035	6	1,161	2,706	1,288
Abdominal pain upper	7,013	6	1,081	2,750	1,063
Rebound effect	6,938	6	237	67	1
Condition aggravated	6,578	6	1,595	2,911	1,475
Arthralgia	6,471	6	1,238	2,493	1,292
Dyspepsia	6,454	6	613	1,852	664
Hypertension	6,248	6	1,861	2,778	1,235
Rash	6,087	6	1,259	2,548	1,344