Azole Antifungal [EPC] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Drug ineffective | 11,354 | 15 | 3,037 | 3,362 | 854 |
| Off label use | 5,407 | 13 | 1,063 | 1,711 | 352 |
| Drug interaction | 3,419 | 9 | 262 | 1,443 | 361 |
| Condition aggravated | 2,992 | 11 | 660 | 1,033 | 342 |
| Vulvovaginal burning sensation | 2,413 | 5 | 0 | 5 | 1 |
| Product use in unapproved indication | 2,400 | 11 | 360 | 567 | 143 |
| Pyrexia | 2,121 | 11 | 476 | 1,266 | 221 |
| Headache | 1,764 | 12 | 256 | 707 | 92 |
| Nausea | 1,730 | 10 | 203 | 852 | 97 |
| Rash | 1,698 | 13 | 193 | 416 | 100 |
| Death | 1,586 | 9 | 1,578 | 357 | 120 |
| Product use issue | 1,580 | 9 | 252 | 230 | 45 |
| Pain | 1,541 | 11 | 220 | 676 | 62 |
| Pruritus | 1,430 | 13 | 19 | 222 | 22 |
| Dyspnoea | 1,399 | 11 | 331 | 831 | 306 |
| Erythema | 1,367 | 10 | 127 | 444 | 17 |
| Vulvovaginal pain | 1,274 | 5 | 0 | 5 | 1 |
| Drug hypersensitivity | 1,229 | 10 | 141 | 224 | 44 |
| Diarrhoea | 1,124 | 8 | 277 | 520 | 112 |
| Anaemia | 1,111 | 9 | 277 | 856 | 160 |
| Fatigue | 1,108 | 10 | 203 | 416 | 79 |
| Pneumonia | 1,061 | 9 | 444 | 701 | 131 |
| Drug ineffective for unapproved indication | 1,057 | 9 | 309 | 261 | 75 |
| Drug resistance | 1,044 | 7 | 406 | 335 | 80 |
| Hypersensitivity | 1,035 | 11 | 111 | 123 | 19 |
| Acute kidney injury | 1,028 | 9 | 241 | 695 | 165 |
| Treatment failure | 1,011 | 8 | 357 | 199 | 74 |
| Therapeutic product effect incomplete | 1,006 | 9 | 86 | 554 | 188 |
| Multiple organ dysfunction syndrome | 960 | 7 | 815 | 551 | 234 |
| Aspergillus infection | 939 | 5 | 392 | 491 | 85 |