CTLA-4-directed Antibody Interactions [MoA] — Common Side Effects

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Side Effect	Total Reports	Drugs	Deaths	Hosp.	Life-Threat.
Death	3,826	2	3,825	302	51
Malignant neoplasm progression	3,364	2	1,592	1,547	286
Diarrhoea	2,693	2	336	1,738	240
Off label use	2,141	2	531	759	136
Colitis	2,103	2	319	1,305	195
Pyrexia	1,974	2	258	1,479	169
Rash	1,604	2	171	706	123
Fatigue	1,494	2	183	805	79
Intentional product use issue	1,334	2	563	351	70
Nausea	1,220	2	150	807	68
Immune-mediated enterocolitis	1,044	2	86	538	95
Decreased appetite	1,027	2	145	689	72
Hypophysitis	996	2	67	521	91
Pneumonitis	978	2	264	619	156
Vomiting	965	2	138	740	73
Pneumonia	963	2	286	761	147
Dyspnoea	963	2	188	683	115
Adrenal insufficiency	896	2	94	604	98
Adverse event	870	1	34	87	16
Acute kidney injury	852	2	185	713	175
Pruritus	801	2	61	342	29
Hypothyroidism	794	2	90	460	77
Headache	727	2	37	444	26
Anaemia	669	2	148	466	65
Sepsis	644	2	290	538	183
Malaise	635	2	90	406	42
Asthenia	632	2	97	413	55
Hepatitis	616	2	101	300	67
Dehydration	612	2	113	551	60
Weight decreased	586	2	52	310	33