Folate Analog Metabolic Inhibitor [EPC] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Drug ineffective | 71,012 | 3 | 2,840 | 9,966 | 2,968 |
| Rheumatoid arthritis | 29,300 | 2 | 2,121 | 6,696 | 2,662 |
| Off label use | 25,719 | 4 | 3,731 | 8,543 | 3,825 |
| Pain | 23,993 | 3 | 2,021 | 6,032 | 2,775 |
| Drug intolerance | 22,684 | 3 | 1,508 | 4,311 | 2,012 |
| Arthralgia | 21,991 | 2 | 1,784 | 5,818 | 2,156 |
| Fatigue | 20,763 | 3 | 2,096 | 5,766 | 2,641 |
| Nausea | 19,923 | 3 | 1,702 | 6,450 | 2,152 |
| Joint swelling | 17,703 | 2 | 1,964 | 4,459 | 2,564 |
| Drug hypersensitivity | 16,743 | 2 | 1,417 | 4,005 | 1,814 |
| Rash | 16,288 | 3 | 2,228 | 5,233 | 2,586 |
| Condition aggravated | 15,213 | 2 | 1,995 | 4,986 | 2,281 |
| Treatment failure | 14,754 | 2 | 1,199 | 2,616 | 1,455 |
| Alopecia | 14,475 | 2 | 1,675 | 3,252 | 2,181 |
| Diarrhoea | 13,740 | 4 | 2,245 | 5,617 | 2,365 |
| Abdominal discomfort | 13,267 | 2 | 1,789 | 3,613 | 2,199 |
| Contraindicated product administered | 13,121 | 1 | 1,305 | 3,339 | 1,744 |
| Headache | 11,948 | 3 | 1,717 | 4,483 | 2,006 |
| Vomiting | 11,870 | 3 | 2,118 | 5,647 | 2,472 |
| Synovitis | 11,451 | 1 | 1,943 | 3,783 | 2,328 |
| Arthropathy | 10,989 | 2 | 1,650 | 3,891 | 2,214 |
| Pneumonia | 10,975 | 3 | 2,756 | 5,591 | 1,982 |
| Pyrexia | 10,969 | 3 | 1,885 | 6,432 | 2,184 |
| Swelling | 10,723 | 2 | 1,908 | 3,130 | 2,305 |
| Peripheral swelling | 10,702 | 2 | 1,539 | 3,690 | 1,702 |
| Infection | 10,618 | 3 | 1,990 | 3,891 | 1,594 |
| Malaise | 10,251 | 3 | 1,701 | 3,991 | 1,935 |
| Pain in extremity | 10,024 | 2 | 1,217 | 3,061 | 1,257 |
| Hypersensitivity | 9,920 | 2 | 1,627 | 3,511 | 2,014 |
| Musculoskeletal stiffness | 9,918 | 2 | 1,486 | 3,013 | 1,823 |