Full Opioid Agonists [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Drug dependence | 224,872 | 11 | 27,375 | 14,161 | 922 |
| Overdose | 144,628 | 12 | 56,230 | 11,344 | 2,354 |
| Pain | 120,246 | 12 | 6,373 | 11,268 | 3,346 |
| Emotional distress | 96,276 | 10 | 2,342 | 1,913 | 184 |
| Death | 94,298 | 12 | 94,185 | 3,476 | 321 |
| Toxicity to various agents | 81,798 | 12 | 67,136 | 14,924 | 2,303 |
| Drug withdrawal syndrome | 75,914 | 10 | 3,634 | 4,229 | 487 |
| Drug abuse | 48,318 | 11 | 30,668 | 8,531 | 1,136 |
| Drug hypersensitivity | 33,766 | 11 | 2,756 | 4,500 | 2,347 |
| Dependence | 33,414 | 9 | 3,752 | 596 | 78 |
| Drug ineffective | 31,434 | 12 | 3,401 | 8,789 | 3,116 |
| Nausea | 21,193 | 12 | 3,790 | 8,198 | 2,700 |
| Anxiety | 20,436 | 11 | 2,407 | 4,562 | 1,532 |
| Drug withdrawal syndrome neonatal | 19,678 | 10 | 343 | 2,748 | 58 |
| Depression | 18,671 | 9 | 3,619 | 4,769 | 1,962 |
| Vomiting | 18,653 | 12 | 4,599 | 7,922 | 3,353 |
| Foetal exposure during pregnancy | 17,339 | 12 | 527 | 3,138 | 161 |
| Off label use | 16,210 | 11 | 4,543 | 7,347 | 3,962 |
| Fatigue | 14,956 | 9 | 4,144 | 6,553 | 3,065 |
| Headache | 14,504 | 12 | 3,509 | 5,858 | 2,558 |
| Dyspnoea | 12,873 | 12 | 3,467 | 5,748 | 2,548 |
| Rash | 12,030 | 12 | 3,461 | 4,878 | 2,980 |
| Completed suicide | 11,853 | 10 | 11,779 | 2,189 | 166 |
| Maternal exposure during pregnancy | 11,758 | 11 | 2,567 | 3,261 | 2,407 |
| Somnolence | 11,753 | 11 | 2,000 | 4,929 | 976 |
| Confusional state | 11,679 | 11 | 3,207 | 6,579 | 3,034 |
| Constipation | 11,501 | 11 | 1,707 | 4,730 | 527 |
| Malaise | 11,112 | 12 | 3,051 | 5,321 | 2,524 |
| Insomnia | 10,731 | 11 | 2,844 | 3,840 | 2,156 |
| Arthralgia | 10,522 | 10 | 3,352 | 5,033 | 2,704 |